Abstract
During the past year, dramatic progress has been achieved in our understanding of Drosophila immune reactions. The completion of the Drosophila genome sequencing project, microarray analysis and the use of genetic screens have led to the identification of several new genes required to combat microbial infection, filling in some important gaps in the understanding of innate immunity. At the same time, this insect was used as a model for the study of host-pathogen interactions. The recent major advances on the mechanisms by which this insect defends itself against intrusion of pathogens are discussed in this review.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antibody Formation / genetics
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Antigens, Bacterial / blood*
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Antimicrobial Cationic Peptides / immunology*
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Antimicrobial Cationic Peptides / physiology
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Bacterial Infections / immunology*
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Bacterial Infections / prevention & control*
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Blood Coagulation / immunology
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Cell Differentiation
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DNA-Binding Proteins / immunology*
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DNA-Binding Proteins / pharmacology
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Drosophila / anatomy & histology
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Drosophila / immunology*
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Drosophila Proteins / immunology*
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Drosophila Proteins / pharmacology
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Fat Body / immunology*
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Hemocytes / physiology*
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Host-Parasite Interactions
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Immunity, Cellular / genetics*
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Immunity, Innate
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Janus Kinase 1
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Melanins / biosynthesis*
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Melanins / immunology
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Membrane Glycoproteins / immunology*
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Membrane Glycoproteins / pharmacology
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Models, Biological
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Protein-Tyrosine Kinases / immunology*
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Protein-Tyrosine Kinases / pharmacology
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Receptors, Cell Surface*
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STAT Transcription Factors
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Signal Transduction
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Toll-Like Receptors
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Trans-Activators / immunology*
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Trans-Activators / pharmacology
Substances
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Antigens, Bacterial
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Antimicrobial Cationic Peptides
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DNA-Binding Proteins
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Drosophila Proteins
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Melanins
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Membrane Glycoproteins
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Receptors, Cell Surface
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STAT Transcription Factors
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Stat92E protein, Drosophila
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Tl protein, Drosophila
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Toll-Like Receptors
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Trans-Activators
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imd protein, Drosophila
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Protein-Tyrosine Kinases
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Janus Kinase 1