A bioartificial liver--state of the art

Science. 2002 Feb 8;295(5557):1005-9. doi: 10.1126/science.1068660.


End-stage liver disease is treated by liver transplantation, but donor organ shortages remain a serious problem. This has prompted the design of bioartificial liver devices to "bridge" patients until they either recover or receive a liver transplant. In these devices, patient plasma is circulated extracorporeally through a bioreactor that houses liver cells (hepatocytes) sandwiched between artificial plates or capillaries.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bioreactors
  • Cells, Cultured
  • Clinical Trials as Topic
  • Equipment Design
  • Hepatocytes / cytology
  • Hepatocytes / metabolism*
  • Hepatocytes / physiology
  • Humans
  • Liver Failure / therapy*
  • Liver Failure, Acute / therapy*
  • Liver, Artificial*
  • Plasma
  • Stem Cells / physiology