Monocytes and T lymphocytes in HIV-1-positive patients express HLA-G molecule

AIDS. 2002 Feb 15;16(3):347-51. doi: 10.1097/00002030-200202150-00005.


Objective: To study the expression of HLA-G on peripheral blood mononuclear cells (PBMC) from HIV-1-infected individuals in order to determine whether this molecule is induced as a consequence of HIV-1 infection.

Design: A total of 23 HIV-positive individuals in different stages of the disease were studied.

Methods: Flow cytometric analysis and Western blot were used to measure HLA-G expression on PBMC obtained from HIV-positive and control individuals.

Results: Most of the monocytes obtained from HIV-1-infected individuals express HLA-G, whereas only a very low proportion of monocytes from healthy individuals express this molecule. When T lymphocytes from HIV-1 infections were studied, it was found that 30% of them express HLA-G, whereas only 1% were HLA-G-positive in healthy individuals. HLA-G expression was also confirmed by Western blot using specific anti-HLA-G monoclonal antibodies.

Conclusion: The synthesis of HLA-G is increased in monocytes and certain T lymphocytes from HIV-1-infected individuals.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blotting, Western
  • Case-Control Studies
  • Cell Line
  • Flow Cytometry
  • HIV Infections / immunology*
  • HIV-1
  • HLA Antigens / biosynthesis
  • HLA Antigens / blood*
  • HLA Antigens / genetics
  • HLA-G Antigens
  • Histocompatibility Antigens Class I / biosynthesis
  • Histocompatibility Antigens Class I / blood*
  • Histocompatibility Antigens Class I / genetics
  • Humans
  • Monocytes / immunology*
  • T-Lymphocytes / immunology*
  • Transfection


  • HLA Antigens
  • HLA-G Antigens
  • Histocompatibility Antigens Class I