Localization of autosomal recessive early-onset parkinsonism to chromosome 1p36 (PARK7) in an independent dataset

Ann Neurol. 2002 Feb;51(2):253-6. doi: 10.1002/ana.10106.


Two new loci, PARK6 and PARK7, for autosomal recessive early-onset parkinsonism have recently been identified on chromosome 1p, in single large pedigrees. Among 4 autosomal recessive early-onset families analyzed here, 2 supported linkage to PARK7, 1 with conclusive evidence. These data confirm localization of autosomal recessive early-onset parkinsonism to PARK7, suggesting it to be a frequent locus. Assignment of families to either PARK6 or PARK7 might be difficult because of the proximity of the two loci on chromosome 1p.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age of Onset
  • Chromosomes, Human, Pair 1*
  • Family Health
  • Female
  • Humans
  • Ligases / genetics
  • Lod Score
  • Male
  • Middle Aged
  • Parkinsonian Disorders / genetics*
  • Pedigree
  • Ubiquitin-Protein Ligases*


  • Ubiquitin-Protein Ligases
  • parkin protein
  • Ligases