Application of a radioreceptorassay of human chorionic gonadotropin in the diagnosis of early abortion

Fertil Steril. 1975 Nov;26(11):1105-12. doi: 10.1016/s0015-0282(16)41478-0.


A radioreceptorassay for human chorionic gonadotropin (hCG) was used to detect pregnancy as early as 6 to 8 days following conception and to predict spontaneous abortion as early as 8 to 10 days after conception in subjects whose hCG levels were lower than those occurring during normal pregnancy of the same duration. The evidence for the specific measurement of hCG was further provided by the correlation of plasma hCG levels measured by radioimmunoassay using antisera specific for hCG-beta and radioreceptorassay of hCG. By virtue of its sensitivity and specificity, the radioreceptorassay of hCG allowed early and accurate prediction of spontaneous abortion in 15 patients.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Abortion, Threatened / diagnosis*
  • Antibodies / isolation & purification
  • Chorionic Gonadotropin / blood*
  • Chorionic Gonadotropin / immunology
  • Female
  • Humans
  • Pregnancy
  • Radioimmunoassay
  • Radioligand Assay*


  • Antibodies
  • Chorionic Gonadotropin