The art and design of genetic screens: Arabidopsis thaliana

Nat Rev Genet. 2002 Feb;3(2):124-36. doi: 10.1038/nrg730.


Molecular genetic studies rely on well-characterized organisms that can be easily manipulated. Arabidopsis thaliana--the model system of choice for plant biologists--allows efficient analysis of plant function, combining classical genetics with molecular biology. Although the complete sequence of the Arabidopsis genome allows the rapid discovery of the molecular basis of a characterized mutant, functional characterization of the Arabidopsis genome depends on well-designed forward genetic screens, which remain a powerful strategy to identify genes that are involved in many aspects of the plant life cycle.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alleles
  • Arabidopsis / genetics*
  • Arabidopsis / growth & development
  • Gene Expression
  • Genes, Reporter
  • Genetic Engineering
  • Genetic Variation
  • Genome, Plant
  • Models, Genetic
  • Molecular Biology
  • Mutagenesis, Insertional
  • Mutation
  • Phenotype
  • Plants, Genetically Modified