Successful pregnancy outcome in a lung transplant recipient with tacrolimus immunosuppression. A case report

J Reprod Med. 2002 Jan;47(1):60-2.


Background: The use of tacrolimus (FK506, PROGRAF) in pregnant lung transplant recipients has been very rarely reported.

Case: A 32-year-old woman, gravida 1, para 0, had previously undergone a unilateral lung transplant secondary to pulmonary fibrosis. Four years later she spontaneously conceived. During pregnancy, she was maintained on an immunosuppressive regimen of tacrolimus and prednisone. Bi-weekly pulmonary function testing remained unchanged until 34 weeks' gestation. At that time, labor was induced due to concern for allograft rejection. A healthy, 2,208-g, female infant was born via an uncomplicated vaginal delivery. Postpartum transbronchial biopsy showed minimal acute cellular rejection.

Conclusion: Lung transplant recipients may achieve successful pregnancy outcomes with the use of tacrolimus.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Female
  • Gestational Age
  • Humans
  • Immunosuppressive Agents / administration & dosage*
  • Lung Transplantation / immunology*
  • Pregnancy
  • Pregnancy Complications / prevention & control*
  • Pregnancy Outcome*
  • Pregnancy, High-Risk*
  • Prognosis
  • Pulmonary Fibrosis / surgery
  • Tacrolimus / administration & dosage*
  • Transplantation Immunology


  • Immunosuppressive Agents
  • Tacrolimus