Purpose: To evaluate whether follicle maturing drugs used in lower dosages for luteal phase defects rather than controlled ovarian hyperstimulation may have an adverse effect on successful implantation.
Methods: Unique case report.
Results: A 40-year-old woman who failed to conceive after six years of follicle maturing drugs with or without progesterone supplementation and four years of in vitro fertilization with embryo transfer (92 embryos transferred in 10 cycles) successfully conceived with the first cycle after the exclusive use of vaginal progesterone in the luteal phase.
Conclusions: This case provides convincing evidence that for some women follicle maturing drugs, even when used in lower dosages, can adversely affect the uterine environment.