Coupling of folding and binding for unstructured proteins

Curr Opin Struct Biol. 2002 Feb;12(1):54-60. doi: 10.1016/s0959-440x(02)00289-0.


There are now numerous examples of proteins that are unstructured or only partially structured under physiological conditions and yet are nevertheless functional. Such proteins are especially prevalent in eukaryotes. In many cases, intrinsically disordered proteins adopt folded structures upon binding to their biological targets. Many new examples of coupled folding and binding events have been reported recently, providing new insights into mechanisms of molecular recognition.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • DNA-Binding Proteins / physiology
  • Eukaryotic Cells
  • Humans
  • Protein Binding / physiology*
  • Protein Folding*
  • Signal Transduction
  • Zinc Fingers / physiology


  • DNA-Binding Proteins