Emc, a negative HLH regulator with multiple functions in Drosophila development

Oncogene. 2001 Dec 20;20(58):8299-307. doi: 10.1038/sj.onc.1205162.

Abstract

Expression and functional analyses of Emc have demonstrated that it is a prototype for a protein required for multiple processes in development. Initially characterized as a negative regulator of sensory organ development, it was later found to regulate many other developmental processes and cell proliferation. Its ability to block the function of bHLH proteins by forming heterodimers, which are ineffective in DNA binding, accounts for the role of Emc in preventing the acquisition of several cell fates which are under the control of bHLH proteins. However, while maintaining this repressive molecular mechanism, emc also appears to act as a positive regulator of differentiation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Basic Helix-Loop-Helix Transcription Factors
  • Cell Division
  • DNA-Binding Proteins / antagonists & inhibitors
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / deficiency
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology*
  • Dimerization
  • Drosophila Proteins / chemistry
  • Drosophila Proteins / genetics
  • Drosophila Proteins / physiology*
  • Drosophila melanogaster / embryology
  • Drosophila melanogaster / genetics
  • Drosophila melanogaster / growth & development
  • Drosophila melanogaster / physiology*
  • Embryo, Nonmammalian / physiology
  • Embryonic and Fetal Development / genetics
  • Embryonic and Fetal Development / physiology
  • Epidermis / embryology
  • Epidermis / innervation
  • Eye / embryology
  • Eye / growth & development
  • Eye Proteins / genetics
  • Eye Proteins / physiology
  • Gene Expression Regulation, Developmental / genetics
  • Gene Expression Regulation, Developmental / physiology*
  • Helix-Loop-Helix Motifs
  • Inhibitor of Differentiation Proteins
  • Larva
  • Malpighian Tubules / embryology
  • Malpighian Tubules / growth & development
  • Mice
  • Mice, Knockout
  • Models, Biological
  • Morphogenesis / genetics
  • Morphogenesis / physiology
  • Neoplasm Proteins*
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / physiology
  • Nuclear Proteins / genetics
  • Nuclear Proteins / physiology
  • Repressor Proteins*
  • Sense Organs / embryology
  • Sense Organs / physiology
  • Trachea / embryology
  • Trachea / growth & development
  • Transcription Factors / antagonists & inhibitors
  • Transcription Factors / genetics
  • Transcription Factors / physiology
  • Wings, Animal / blood supply

Substances

  • Basic Helix-Loop-Helix Transcription Factors
  • DNA-Binding Proteins
  • Da protein, Drosophila
  • Drosophila Proteins
  • Eye Proteins
  • Inhibitor of Differentiation Proteins
  • Neoplasm Proteins
  • Nerve Tissue Proteins
  • Nuclear Proteins
  • Repressor Proteins
  • Transcription Factors
  • ac protein, Drosophila
  • emc protein, Drosophila
  • sc protein, Drosophila
  • ID3 protein, human