Id Proteins in Cell Cycle Control and Cellular Senescence

Oncogene. 2001 Dec 20;20(58):8317-25. doi: 10.1038/sj.onc.1205092.

Abstract

The Id family of helix-loop-helix (HLH) proteins are thought to affect the balance between cell growth and differentiation by negatively regulating the function of basic-helix-loop-helix (bHLH) transcription factors. Although it has been suggested for some time that Id is involved in cell cycle regulation, little is known about the molecular mechanism of this control. Recent studies, however, have revealed that Id binds to important cell cycle regulatory proteins other than bHLH proteins. Two such proteins, pRB (retinoblastoma tumour suppressor protein) family proteins and Ets-family transcription factors are known to play key roles in cell cycle regulation, transformation and tumour suppression. Through the characterization of these pathways we will begin to understand the mechanisms by which Id controls normal and abnormal cell cycle progression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle / genetics
  • Cell Cycle / physiology*
  • Cell Cycle Proteins / physiology
  • Cell Division
  • Cell Transformation, Neoplastic / genetics
  • Cellular Senescence / genetics
  • Cellular Senescence / physiology*
  • Cyclin-Dependent Kinase Inhibitor p16 / physiology
  • DNA Replication
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology*
  • Dimerization
  • Fibroblasts / cytology
  • Gene Expression Regulation, Developmental
  • Genes, Tumor Suppressor
  • Genes, p16
  • Genes, ras
  • Helix-Loop-Helix Motifs
  • Humans
  • Inhibitor of Differentiation Protein 1
  • Inhibitor of Differentiation Protein 2
  • Inhibitor of Differentiation Proteins
  • MAP Kinase Signaling System
  • Mammals / genetics
  • Mammals / physiology
  • Mice
  • Models, Biological
  • Multigene Family*
  • Neoplasm Proteins*
  • Repressor Proteins*
  • Retinoblastoma Protein / physiology
  • Transcription Factors / chemistry
  • Transcription Factors / genetics
  • Transcription Factors / physiology*
  • Transcription, Genetic

Substances

  • Cell Cycle Proteins
  • Cyclin-Dependent Kinase Inhibitor p16
  • DNA-Binding Proteins
  • ID1 protein, human
  • ID2 protein, human
  • ID4 protein, human
  • Idb1 protein, mouse
  • Idb2 protein, mouse
  • Idb4 protein, mouse
  • Inhibitor of Differentiation Protein 1
  • Inhibitor of Differentiation Protein 2
  • Inhibitor of Differentiation Proteins
  • Neoplasm Proteins
  • Repressor Proteins
  • Retinoblastoma Protein
  • Transcription Factors
  • ID3 protein, human