Rheumatoid arthritis. The genetic components

Rheum Dis Clin North Am. 2002 Feb;28(1):1-15, v. doi: 10.1016/s0889-857x(03)00066-8.


Rheumatoid arthritis is a multifactorial disease, with genetic, environmental, and stochastic components to its susceptibility. The search for susceptibility genes is still in progress. Preliminary results suggest the involvement of multiple genes, each with relatively modest effect. Genes within the major histocompatibility complex appear to have the strongest influence on disease susceptibility.

Publication types

  • Review

MeSH terms

  • Arthritis, Rheumatoid / epidemiology
  • Arthritis, Rheumatoid / genetics*
  • Genetic Predisposition to Disease
  • HLA Antigens / genetics
  • Humans
  • Prevalence


  • HLA Antigens