Receptors of the PAR family as a link between blood coagulation and inflammation

Biochemistry (Mosc). 2002 Jan;67(1):65-74. doi: 10.1023/a:1013952114485.

Abstract

Blood coagulation plays a key role among numerous mediating systems that are activated in inflammation. Receptors of the PAR family serve as sensors of serine proteinases of the blood clotting system in the target cells involved in inflammation. Activation of PAR-1 by thrombin and of PAR-2 by factor Xa leads to a rapid expression and exposure on the membrane of endothelial cells of both adhesive proteins that mediate an acute inflammatory reaction and of the tissue factor that initiates the blood coagulation cascade. Certain other receptors (EPR-1, thrombomodulin, etc.), which can modulate responses of the cells activated by proteinases through PAR receptors, are also involved in the association of coagulation and inflammation together with the receptors of the PAR family. The presence of PAR receptors on mast cells is responsible for their reactivity to thrombin and factor Xa and defines their contribution to the association of inflammation and blood clotting processes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Blood Coagulation*
  • Humans
  • Inflammation*
  • Models, Biological
  • Platelet Membrane Glycoproteins / metabolism
  • Protein Binding
  • Receptor, PAR-1
  • Receptor, PAR-2
  • Receptors, Cell Surface / metabolism
  • Receptors, Thrombin / metabolism*
  • Thrombin / metabolism

Substances

  • Platelet Membrane Glycoproteins
  • Receptor, PAR-1
  • Receptor, PAR-2
  • Receptors, Cell Surface
  • Receptors, Thrombin
  • factor X receptors
  • protease-activated receptor 3
  • Thrombin
  • protease-activated receptor 4