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. 2002 Feb;11(1):79-86.
doi: 10.1046/j.0962-1075.2001.00311.x.

A High Affinity Serotonin- And Histamine-Binding Lipocalin From Tick Saliva

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A High Affinity Serotonin- And Histamine-Binding Lipocalin From Tick Saliva

S Sangamnatdej et al. Insect Mol Biol. .

Abstract

To overcome the inflammatory response in its host, the cattle-feeding, brown ear tick secretes histamine-binding proteins into the feeding site. These proteins are beta-barrels with two internal binding sites: a high-affinity (H) site for histamine and a site (L) for which the natural ligand is unknown. Here we report a related protein (SHBP), secreted by a rodent- and cattle-feeding tick, that traps both histamine and serotonin. The histamine-binding H site is well conserved in SHBP, whereas residue changes in the L-like site are consistent with binding of the bulkier serotonin molecule. As histamine is a key inflammatory mediator in cattle, while serotonin takes on this role in rodents, the diversification of these tick proteins may reflect host adaptation.

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