ECM remodeling regulates angiogenesis: endothelial integrins look for new ligands

Sci STKE. 2002 Feb 12;2002(119):pe7. doi: 10.1126/stke.2002.119.pe7.


The process of angiogenesis is a dynamic one. Vascular endothelial cells are changing at the same time the extracellular matrix is being remodeled. Stupack and Cheresh discuss how remodeling of the extracellular matrix (ECM) and changes in the endothelial cell protein production and integrin expression contribute to the complex process of new blood vessel growth from an existing vascular bed.

Publication types

  • Review

MeSH terms

  • Animals
  • Endothelium, Vascular / metabolism
  • Endothelium, Vascular / physiology*
  • Extracellular Matrix / metabolism
  • Extracellular Matrix / physiology*
  • Extracellular Matrix Proteins / metabolism
  • Extracellular Matrix Proteins / physiology*
  • Humans
  • Integrins / metabolism*
  • Ligands
  • Neovascularization, Physiologic / physiology*


  • Extracellular Matrix Proteins
  • Integrins
  • Ligands