The influence of phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor

Nutr Neurosci. 2001;4(3):169-78. doi: 10.1080/1028415x.2001.11747360.


There have been previous reports that supplements of phosphatidylserine (PS) blunted the release of cortisol in response to exercise stress and that it improved mood. The present study extended these observations by considering whether PS supplementation influenced subjective feelings of stress and the change in heart rate when a stressful mental arithmetic task was performed. In young adults, with neuroticism scores above rather than below the median, the taking of 300mg PS each day for a month was associated with feeling less stressed and having a better mood. The study for the first time reports an improvement in mood following PS supplementation in a sub-group of young healthy adults.

MeSH terms

  • Acute Disease
  • Adult
  • Affect / drug effects*
  • Heart Rate / drug effects*
  • Humans
  • Male
  • Mathematics
  • Mental Processes
  • Phosphatidylserines / adverse effects
  • Phosphatidylserines / pharmacology*
  • Reference Values
  • Stress, Physiological / etiology
  • Stress, Physiological / physiopathology*
  • Stress, Physiological / psychology*


  • Phosphatidylserines