Botulinum toxin A for palmar hyperhidrosis

J Eur Acad Dermatol Venereol. 2001 Nov;15(6):555-8. doi: 10.1046/j.1468-3083.2001.00350.x.


Objective: We evaluated the efficacy and safety of intracutaneous injections of botulinum toxin A on severe palmar hyperhidrosis.

Methods: Ten patients with recalcitrant palmar hyperhidrosis were treated with intercutaneous injections of botulinum toxin A (Botox; 200 U for each hand). Patients were followed up to 23 months (mean +/- SD: 12.1 +/- 6.2 months). RESULTS Botulinum toxin significantly reduced abnormal sweating within 1 week in 100% of the patients. In six patients with a follow-up of 12 months or more the antisudorific effect lasted 12.3 +/- 5.5 months. The longest response duration was 22 months. Repeated treatment was performed in five patients with unchanged clinical efficacy. The only side-effect was tolerable pain from the intracutaneous injections in patients where a nerve block was not performed.

Conclusions: Botulinum toxin A (200 U Botox per palm) was able to induce long-term remission in palmar hyperhidrosis without significant acute and long-term side-effects. Strictly intracutaneous injection of small volumes is recommended. So far, response to repeated treatments did not show evidence of neutralizing antibody induction.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Adult
  • Botulinum Toxins, Type A / administration & dosage*
  • Chi-Square Distribution
  • Dose-Response Relationship, Drug
  • Female
  • Follow-Up Studies
  • Hand
  • Humans
  • Hyperhidrosis / diagnosis
  • Hyperhidrosis / therapy*
  • Injections, Subcutaneous
  • Male
  • Probability
  • Recurrence
  • Severity of Illness Index
  • Treatment Outcome


  • Botulinum Toxins, Type A