Lipoic acid confers protection against oxidative injury in non-neuronal and neuronal tissue

Nutr Neurosci. 2001;4(6):419-38. doi: 10.1080/1028415x.2001.11747378.


In the past decade or so, a convincing link between oxidative stress and degenerative conditions has been made and with the knowledge that oxidatiye changes may actually trigger deterioration in cell function, a great deal of energy has focussed on identifying agents which may have possible therapeutic value in combating oxidative changes. One agent which has received attention, because of its powerful antioxidative effects, particularly in neuronal tissue, is lipoic acid.

Publication types

  • Review

MeSH terms

  • Aging
  • Animals
  • Antioxidants / pharmacology
  • Glutamic Acid / pharmacology
  • Humans
  • Long-Term Potentiation
  • Mitochondria / drug effects
  • Mitochondria / physiology
  • Nervous System Diseases / drug therapy
  • Nervous System Diseases / etiology
  • Neurodegenerative Diseases / drug therapy
  • Neurons / drug effects*
  • Oxidative Stress*
  • Reperfusion Injury / drug therapy
  • Signal Transduction / drug effects
  • Thioctic Acid / pharmacology*
  • Thioctic Acid / therapeutic use


  • Antioxidants
  • Glutamic Acid
  • Thioctic Acid