Insulin sensitivity and fertility

Roy Taylor; Philippa J. Marsden

doi:10.1080/1464727002000198701

Insulin sensitivity and fertility

Hum Fertil (Camb). 2000;3(1):65-69. doi: 10.1080/1464727002000198701.

Authors

Roy Taylor¹, Philippa J. Marsden

Affiliation

¹ Human Metabolism Research Group, Medical School, Newcastle upon Tyne, UK.

PMID: 11844356
DOI: 10.1080/1464727002000198701

Abstract

This review sets in context significant recent advances in the understanding of the pathophysiology of polycystic ovary syndrome (PCOS). The occurrence of variable insulin sensitivity in individuals is discussed. Information is presented to demonstrate that prolonged anovulation decreases insulin sensitivity and, conversely, that improvement in insulin sensitivity normalizes ovarian function in PCOS. In addition, a meta-analysis of studies on metformin and troglitazone treatment in PCOS is presented.