Regulation of cyclin-Cdk activity in mammalian cells

Cell Mol Life Sci. 2002 Jan;59(1):126-42. doi: 10.1007/s00018-002-8410-1.


Cell cycle progression is driven by the coordinated regulation of the activities of cyclin-dependent kinases (Cdks). Of the several mechanisms known to regulate Cdk activity in response to external signals, regulation of cyclin gene expression, post-translational modification of Cdks by phosphorylation-dephosphorylation cascades, and the interaction of cyclin/Cdk complexes with protein inhibitors have been thoroughly studied. During recent years, much attention has also been given to mechanisms that regulate protein degradation by the ubiquitin/proteasome pathway, as well as to the regulation of subcellular localization of the proteins that comprise the intrinsic cell cycle clock. The purpose of the present review is to summarize the most important aspects of the various mechanisms implicated in cell cycle regulation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Cycle*
  • Cyclin-Dependent Kinases / antagonists & inhibitors
  • Cyclin-Dependent Kinases / metabolism*
  • Cyclins / metabolism*
  • Enzyme Inhibitors / metabolism
  • Humans
  • Mammals / metabolism
  • Phosphorylation
  • Protein Binding
  • Protein Processing, Post-Translational
  • Protein Transport


  • Cyclins
  • Enzyme Inhibitors
  • Cyclin-Dependent Kinases