The Ror receptor tyrosine kinase family

Cell Mol Life Sci. 2002 Jan;59(1):83-96. doi: 10.1007/s00018-002-8407-9.

Abstract

Receptor tyrosine kinases (RTKs) participate in numerous developmental decisions. Ror RTKs are a family of orphan receptors that are related to muscle specific kinase (MuSK) and Trk neurotrophin receptors. MuSK assembles acetylcholine receptors at the neuromuscular junction, and Trk receptors function in the developing nervous system (reviewed in [3-5]). Rors have been identified in nematodes, insects and mammals. Recent studies have begun to shed light on Ror function during development. In most species, Rors are expressed in many tissue types during development. Analyses of mutants that are defective in the single nematode Ror demonstrate a role in cell migration and in orienting cell polarity. Mice lacking one of the two Ror gene products display defects in bone and heart formation. Similarly, two different human bone development disorders, dominant brachydactyly B and recessive Robinow syndrome, result from mutations in one of the human Ror genes.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Caenorhabditis elegans Proteins
  • Conserved Sequence*
  • Genetic Diseases, Inborn / genetics
  • Humans
  • Molecular Sequence Data
  • Multigene Family
  • Mutation / genetics
  • Protein Sorting Signals
  • Protein Structure, Tertiary
  • Receptor Protein-Tyrosine Kinases / chemistry*
  • Receptor Protein-Tyrosine Kinases / genetics
  • Receptor Protein-Tyrosine Kinases / metabolism*
  • Receptor Tyrosine Kinase-like Orphan Receptors

Substances

  • Caenorhabditis elegans Proteins
  • Protein Sorting Signals
  • CAM-1 protein, C elegans
  • Receptor Protein-Tyrosine Kinases
  • Receptor Tyrosine Kinase-like Orphan Receptors

Associated data

  • GENBANK/A47299