Inhibition of Tumour Invasion and Angiogenesis by Epigallocatechin Gallate (EGCG), a Major Component of Green Tea

Int J Exp Pathol. 2001 Dec;82(6):309-16. doi: 10.1046/j.1365-2613.2001.00205.x.

Abstract

Epidemiological studies have suggested that consumption of green tea may decrease cancer risk. In addition, abundant pre-clinical data from several laboratories have provided convincing evidence that polyphenols present in green tea afford protection against cancer in both in vivo and in vitro studies. Recently, epigallocatechin gallate (EGCG), a putative chemopreventive agent and a major component of green tea, was reported to inhibit tumour invasion and angiogenesis, processes that are essential for tumour growth and metastasis. Understanding the basic principles by which EGCG inhibits tumour invasion and angiogenesis may lead to the development of new therapeutic strategies, in addition to supporting the role of green tea as a cancer chemopreventive agent.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Angiogenesis Inhibitors / therapeutic use
  • Anticarcinogenic Agents / therapeutic use*
  • Catechin / analogs & derivatives
  • Catechin / therapeutic use*
  • Humans
  • Neoplasm Invasiveness / prevention & control*
  • Neoplasms / blood supply
  • Neovascularization, Pathologic / prevention & control*
  • Phytotherapy
  • Plant Extracts / therapeutic use
  • Tea / chemistry*

Substances

  • Angiogenesis Inhibitors
  • Anticarcinogenic Agents
  • Plant Extracts
  • Tea
  • Catechin
  • epigallocatechin gallate