Activities of IRF-1

J Interferon Cytokine Res. 2002 Jan;22(1):5-14. doi: 10.1089/107999002753452610.


Interferon (IFN) regulatory factor-1 (IRF-1) was isolated by virtue of its affinity to specific DNA sequences in the IFN-beta promoter that mediate virus responsiveness. IRF-1 was the first factor identified of the IRF family and was most extensively characterized at the molecular level. Also, its physiologic role in host defense against pathogens, tumor prevention, and development of the immune system was investigated in detail. Even though some of the functions first associated with IRF-1 were later found to be mediated in part or predominantly by other activators of the IRF family of transcription factors, IRF-1 has remained a central paradigm in the transcriptional regulation of the IFN response.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Apoptosis
  • Cell Division
  • Cell Transformation, Neoplastic
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology*
  • Humans
  • Immunity
  • Interferon Regulatory Factor-1
  • Interferons / physiology
  • Phosphoproteins / chemistry
  • Phosphoproteins / genetics
  • Phosphoproteins / physiology*
  • Protein Structure, Tertiary
  • Signal Transduction
  • Transcription Factors / chemistry
  • Transcription Factors / genetics
  • Transcription Factors / physiology*
  • Transcriptional Activation


  • DNA-Binding Proteins
  • IRF1 protein, human
  • Interferon Regulatory Factor-1
  • Phosphoproteins
  • Transcription Factors
  • Interferons