IRF-1 as a negative regulator of cell proliferation

J Interferon Cytokine Res. 2002 Jan;22(1):39-47. doi: 10.1089/107999002753452647.


Numerous evidence has demonstrated the involvement in growth control of interferon (IFN) regulatory factor-1 (IRF-1), which shows tumor suppressor activity. IRF-1 is a well-studied member of the IRF transcription factors that reveals functional diversity in the regulation of cellular response by activating expression of a diverse set of target genes, depending on the cell type and on the specific stimuli. IRF-1 gene rearrangements may be a crucial point in the pathogenesis of some cancer types. Furthermore, different aspects of the tumor suppressor function of IRF-1 may be explained, at least in part, by the observations that IRF-1 is a regulator of cell cycle and apoptosis and that its inactivation accelerates cell transformation. Studies on gene knockout mice contributed greatly to the clarification of these multiple IRF-1 functions. We summarize our current knowledge of the antigrowth effect of IRF-1, focusing also on a more general involvement of IRF-1 in mediating negative regulation of cell growth induced by numerous cytokines and other biologic response modifiers.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Base Sequence
  • Cell Cycle
  • Cell Division
  • Cell Transformation, Neoplastic
  • Cytokines / physiology
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology*
  • Gene Expression Regulation
  • Growth Inhibitors / genetics
  • Growth Inhibitors / physiology
  • Humans
  • Interferon Regulatory Factor-1
  • Mice
  • Phosphoproteins / genetics
  • Phosphoproteins / physiology*
  • Response Elements
  • Transcription Factors / genetics
  • Transcription Factors / physiology
  • Tumor Suppressor Proteins / genetics
  • Tumor Suppressor Proteins / physiology*


  • Cytokines
  • DNA-Binding Proteins
  • Growth Inhibitors
  • IRF1 protein, human
  • Interferon Regulatory Factor-1
  • Irf1 protein, mouse
  • Phosphoproteins
  • Transcription Factors
  • Tumor Suppressor Proteins