Generating samples under a Wright-Fisher neutral model of genetic variation

Bioinformatics. 2002 Feb;18(2):337-8. doi: 10.1093/bioinformatics/18.2.337.


A Monte Carlo computer program is available to generate samples drawn from a population evolving according to a Wright-Fisher neutral model. The program assumes an infinite-sites model of mutation, and allows recombination, gene conversion, symmetric migration among subpopulations, and a variety of demographic histories. The samples produced can be used to investigate the sampling properties of any sample statistic under these neutral models.

MeSH terms

  • Computational Biology
  • Gene Conversion
  • Genetic Variation*
  • Genetics, Population
  • Models, Genetic*
  • Monte Carlo Method
  • Recombination, Genetic
  • Software*