Growth hormone treatment does not alter lower limb asymmetry in children with Russell-Silver syndrome

Horm Res. 2001;56(3-4):114-6. doi: 10.1159/000048102.


Background: Growth hormone (GH) treatment has been proven to have a beneficial effect on growth in children with Russell-Silver syndrome (RSS).

Methods: We describe 7 prepubertal children with RSS and lower limb asymmetry treated with GH for 3 years.

Results: There was a significant increase in height without any significant change in the asymmetry.

Conclusions: We conclude that the rapid growth acceleration to GH treatment does not alter the lower limb asymmetry in children with RSS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Child, Preschool
  • Congenital Abnormalities*
  • Female
  • Fetal Growth Retardation / complications*
  • Growth Disorders / complications*
  • Growth Disorders / drug therapy*
  • Growth Hormone / therapeutic use*
  • Humans
  • Leg Length Inequality / complications*
  • Leg Length Inequality / pathology*
  • Male
  • Syndrome


  • Growth Hormone