Statins and the risk of idiopathic venous thromboembolism

Br J Clin Pharmacol. 2002 Jan;53(1):101-5. doi: 10.1046/j.0306-5251.2001.01523.x.

Abstract

Aims: To evaluate the association between current statin use and the risk of idiopathic venous thromboembolism (VTE).

Methods: A population-based retrospective follow-up with a nested case-control analysis using the General Practice Research Database.

Results: There were 72 cases of idiopathic VTE. Using normolipidaemic nonuse as the reference group, the adjusted relative risks for idiopathic VTE for current/recent statin use, past statin use, past other lipid-lowering drug use, and hyperlipidaemic nonuse were 0.8 (0.3, 2.7), 2.4 (0.6, 10.0), 1.8 (0.4, 7.4), and 0.9 (0.4, 2.0) in the follow-up analysis, and were 1.1 (0.3, 4.3), 3.7 (0.6, 24.1), 2.0 (0.3, 11.6), and 0.4 (0.2, 1.2) in the case-control analysis.

Conclusions: Current statin use was not associated with a reduced risk of idiopathic VTE.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Confidence Intervals
  • Drug Evaluation / statistics & numerical data
  • Female
  • Follow-Up Studies
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
  • Hyperlipidemias / drug therapy
  • Hyperlipidemias / epidemiology
  • Hypolipidemic Agents / therapeutic use*
  • Logistic Models
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Odds Ratio
  • Retrospective Studies
  • Risk Factors
  • Thromboembolism / drug therapy
  • Thromboembolism / epidemiology
  • Thromboembolism / prevention & control*
  • Venous Thrombosis / drug therapy
  • Venous Thrombosis / epidemiology
  • Venous Thrombosis / prevention & control

Substances

  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Hypolipidemic Agents