Generation of Myo-Inositol-Auxotrophic Leishmania Mexicana Mutants by Targeted Replacement of the myo-inositol-1-phosphate Synthase Gene

Mol Biochem Parasitol. 2002 Mar;120(1):151-6. doi: 10.1016/s0166-6851(01)00435-2.

MeSH terms

  • Animals
  • Gene Deletion*
  • Gene Targeting*
  • Inositol / metabolism
  • Leishmania mexicana / genetics
  • Leishmania mexicana / growth & development*
  • Leishmania mexicana / metabolism
  • Leishmania mexicana / pathogenicity
  • Leishmaniasis, Cutaneous / parasitology*
  • Leishmaniasis, Cutaneous / physiopathology
  • Mice
  • Molecular Sequence Data
  • Myo-Inositol-1-Phosphate Synthase / genetics*
  • Myo-Inositol-1-Phosphate Synthase / metabolism
  • Polymerase Chain Reaction
  • Virulence

Substances

  • Inositol
  • Myo-Inositol-1-Phosphate Synthase

Associated data

  • GENBANK/AJ344543
  • GENBANK/AJ344544