Abstract
The flower of Trollius chinensis Bunge is used for treating upper respiratory infections, pharyngitis, tonsillitis, and bronchitis in Chinese folk medicine. The antiviral activities of the crude extract, total flavonoids, orientin, vitexin and proglobeflowery acid isolated from the flowers of T. chinensis against parainfluenza type 3 (Para 3) virus were investigated. The results showed that the crude extract and total flavonoids exhibited a weak antiviral activity against Para 3. Orientin and vitexin demonstrated potent or moderate antiviral activity against Para 3. Proglobeflowery acid showed weak antiviral activity against Para 3.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antiviral Agents / chemistry
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Antiviral Agents / isolation & purification
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Antiviral Agents / pharmacology*
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Cells, Cultured
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Cytopathogenic Effect, Viral / drug effects
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Drug Evaluation, Preclinical / methods
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Drug Evaluation, Preclinical / statistics & numerical data
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Drugs, Chinese Herbal / pharmacology*
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Flavonoids / isolation & purification
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Flavonoids / pharmacology*
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Humans
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Inhibitory Concentration 50
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Parabens / chemistry
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Parabens / isolation & purification
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Parabens / pharmacology*
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Parainfluenza Virus 3, Human / drug effects*
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Parainfluenza Virus 3, Human / growth & development
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Plant Structures
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Ranunculaceae*
Substances
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Antiviral Agents
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Drugs, Chinese Herbal
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Flavonoids
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Parabens
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Plant Extracts
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proglobeflowery acid