Protein transduction technology

Curr Opin Biotechnol. 2002 Feb;13(1):52-6. doi: 10.1016/s0958-1669(02)00284-7.


Intracellular delivery of macromolecules remains problematic because of the bioavailability restriction imposed by the cell membrane. Recent studies on protein transduction domains have circumvented this barrier, however, and have resulted in the delivery of peptides, full-length proteins, iron beads, liposomes, and radioactive isotopes into cells in culture and animal models in vivo.

Publication types

  • Review

MeSH terms

  • Animals
  • Drug Delivery Systems* / methods
  • Humans
  • Protein Structure, Tertiary*
  • Protein Transport*