Abstract
We report a male patient with acute myelogenous leukemia (AML; French-American-British M2) associated with AML1-ETO. Cytogenetic studies showed a complex karyotype including a novel translocation (8;21;14)(q22;q22;q24) in all analyzed cells. This three-way translocation was confirmed with spectral karyotyping. Reverse transcription-polymerase chain reaction analysis for AML1-ETO chimeric transcripts showed the presence of the fusion product with the expected size. Translocation (8;21;14)(q22;q22;q24) is a novel variant of t(8;21)(q22;q22), possibly having a common molecular pathogenetic mechanism.
MeSH terms
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Base Sequence
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Chromosomes, Human, Pair 14*
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Chromosomes, Human, Pair 21*
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Chromosomes, Human, Pair 8*
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Core Binding Factor Alpha 2 Subunit
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DNA Primers
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Humans
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Karyotyping
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Leukemia, Myeloid, Acute / genetics*
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Male
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Middle Aged
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Oncogene Proteins, Fusion / genetics*
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RNA, Messenger / genetics*
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RUNX1 Translocation Partner 1 Protein
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Reverse Transcriptase Polymerase Chain Reaction
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Transcription Factors / genetics*
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Translocation, Genetic*
Substances
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AML1-ETO fusion protein, human
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Core Binding Factor Alpha 2 Subunit
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DNA Primers
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Oncogene Proteins, Fusion
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RNA, Messenger
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RUNX1 Translocation Partner 1 Protein
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Transcription Factors