t(8;21;14)(q22;q22;q24) is a novel variant of t(8;21) with chimeric transcripts of AML1-ETO in acute myelogenous leukemia

Cancer Genet Cytogenet. 2002 Jan 15;132(2):133-5. doi: 10.1016/s0165-4608(01)00550-7.

Abstract

We report a male patient with acute myelogenous leukemia (AML; French-American-British M2) associated with AML1-ETO. Cytogenetic studies showed a complex karyotype including a novel translocation (8;21;14)(q22;q22;q24) in all analyzed cells. This three-way translocation was confirmed with spectral karyotyping. Reverse transcription-polymerase chain reaction analysis for AML1-ETO chimeric transcripts showed the presence of the fusion product with the expected size. Translocation (8;21;14)(q22;q22;q24) is a novel variant of t(8;21)(q22;q22), possibly having a common molecular pathogenetic mechanism.

Publication types

  • Case Reports

MeSH terms

  • Base Sequence
  • Chromosomes, Human, Pair 14*
  • Chromosomes, Human, Pair 21*
  • Chromosomes, Human, Pair 8*
  • Core Binding Factor Alpha 2 Subunit
  • DNA Primers
  • Humans
  • Karyotyping
  • Leukemia, Myeloid, Acute / genetics*
  • Male
  • Middle Aged
  • Oncogene Proteins, Fusion / genetics*
  • RNA, Messenger / genetics*
  • RUNX1 Translocation Partner 1 Protein
  • Reverse Transcriptase Polymerase Chain Reaction
  • Transcription Factors / genetics*
  • Translocation, Genetic*

Substances

  • AML1-ETO fusion protein, human
  • Core Binding Factor Alpha 2 Subunit
  • DNA Primers
  • Oncogene Proteins, Fusion
  • RNA, Messenger
  • RUNX1 Translocation Partner 1 Protein
  • Transcription Factors