I(h) channels contribute to the different functional properties of identified dopaminergic subpopulations in the midbrain

J Neurosci. 2002 Feb 15;22(4):1290-302. doi: 10.1523/JNEUROSCI.22-04-01290.2002.

Abstract

Dopaminergic (DA) midbrain neurons in the substantia nigra (SN) and ventral tegmental area (VTA) are involved in various brain functions such as voluntary movement and reward and are targets in disorders such as Parkinson's disease and schizophrenia. To study the functional properties of identified DA neurons in mouse midbrain slices, we combined patch-clamp recordings with either neurobiotin cell-filling and triple labeling confocal immunohistochemistry, or single-cell RT-PCR. We discriminated four DA subpopulations based on anatomical and neurochemical differences: two calbindin D28-k (CB)-expressing DA populations in the substantia nigra (SN/CB+) or ventral tegmental area (VTA/CB+), and respectively, two calbindin D28-k negative DA populations (SN/CB-, VTA/CB-). VTA/CB+ DA neurons displayed significantly faster pacemaker frequencies with smaller afterhyperpolarizations compared with other DA neurons. In contrast, all four DA populations possessed significant differences in I(h) channel densities and I(h) channel-mediated functional properties like sag amplitudes and rebound delays in the following order: SN/CB- --> VTA/CB- --> SN/CB+ --> VTA/CB+. Single-cell RT-multiplex PCR experiments demonstrated that differential calbindin but not calretinin expression is associated with differential I(h) channel densities. Only in SN/CB- DA neurons, however, I(h) channels were actively involved in pacemaker frequency control. In conclusion, diversity within the DA system is not restricted to distinct axonal projections and differences in synaptic connectivity, but also involves differences in postsynaptic conductances between neurochemically and topographically distinct DA neurons.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / physiology
  • Animals
  • Biological Clocks / physiology
  • Biotin / analogs & derivatives*
  • Calbindin 2
  • Calbindins
  • Cyclic Nucleotide-Gated Cation Channels
  • Dopamine / metabolism*
  • Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
  • Immunohistochemistry
  • In Vitro Techniques
  • Ion Channels / metabolism*
  • Membrane Potentials / physiology
  • Mesencephalon / cytology
  • Mesencephalon / metabolism*
  • Mice
  • Mice, Inbred C57BL
  • Nerve Tissue Proteins / metabolism
  • Neurons / classification
  • Neurons / metabolism*
  • Patch-Clamp Techniques
  • Potassium Channels
  • Pyrimidines / pharmacology
  • RNA, Messenger / biosynthesis
  • Reverse Transcriptase Polymerase Chain Reaction
  • S100 Calcium Binding Protein G / biosynthesis
  • S100 Calcium Binding Protein G / genetics
  • Substantia Nigra / metabolism
  • Ventral Tegmental Area / metabolism

Substances

  • Calb2 protein, mouse
  • Calbindin 2
  • Calbindins
  • Cyclic Nucleotide-Gated Cation Channels
  • Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
  • Ion Channels
  • Nerve Tissue Proteins
  • Potassium Channels
  • Pyrimidines
  • RNA, Messenger
  • S100 Calcium Binding Protein G
  • neurobiotin
  • ICI D2788
  • Biotin
  • Dopamine