A gene-driven approach to the identification of ENU mutants in the mouse

Nat Genet. 2002 Mar;30(3):255-6. doi: 10.1038/ng847. Epub 2002 Feb 19.


The construction of parallel archives of DNA and sperm from mice mutagenized with ethylnitrosurea (ENU) represents a potentially powerful and rapid approach for identifying point mutations in any gene in the mouse genome. We provide support for this approach and report the identification of mutations in the gene (Gjb2) encoding connexin 26, using archives established from the UK ENU mutagenesis program.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Animals
  • Ethylnitrosourea / pharmacology*
  • Female
  • Heterozygote
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C3H
  • Mice, Mutant Strains
  • Mutagens / pharmacology*
  • Mutation*


  • Mutagens
  • Ethylnitrosourea