Identification of functional VEGF receptors on human platelets

FEBS Lett. 2002 Feb 13;512(1-3):107-10. doi: 10.1016/s0014-5793(02)02232-9.


Platelets secrete platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) upon stimulation. We have demonstrated that platelets have functionally active PDGF alpha-receptors, a transmembrane tyrosine kinase involved in negative feedback regulation. Here we demonstrate the presence of the related VEGF receptors fms-like tyrosine kinase-1 and kinase-insert domain region on human platelets. VEGF itself did not cause platelet aggregation. However, addition of exogenous VEGF to SFRLLN or thrombin-stimulated platelets potentiated platelet aggregation. Moreover, thrombin-induced phosphoinositide 3-kinase and mitogen-activated protein kinase activity were enhanced in the presence of VEGF.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood Platelets / drug effects*
  • Endothelial Growth Factors / pharmacology*
  • Humans
  • Lymphokines / pharmacology*
  • Mitogen-Activated Protein Kinases / metabolism
  • Peptide Fragments / pharmacology
  • Phosphatidylinositol 3-Kinases / metabolism
  • Platelet Activation
  • Proto-Oncogene Proteins / isolation & purification*
  • Receptor Protein-Tyrosine Kinases / isolation & purification*
  • Receptors, Growth Factor / isolation & purification*
  • Receptors, Thrombin / metabolism
  • Receptors, Vascular Endothelial Growth Factor
  • Signal Transduction
  • Thrombin / pharmacology
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factor Receptor-1
  • Vascular Endothelial Growth Factors


  • Endothelial Growth Factors
  • Lymphokines
  • Peptide Fragments
  • Proto-Oncogene Proteins
  • Receptors, Growth Factor
  • Receptors, Thrombin
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors
  • thrombin receptor peptide (42-47)
  • Phosphatidylinositol 3-Kinases
  • Receptor Protein-Tyrosine Kinases
  • Receptors, Vascular Endothelial Growth Factor
  • Vascular Endothelial Growth Factor Receptor-1
  • Mitogen-Activated Protein Kinases
  • Thrombin