Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K(+) channel Kv2.1

FEBS Lett. 2002 Feb 13;512(1-3):230-4. doi: 10.1016/s0014-5793(02)02267-6.


We report identification and characterization of Kv6.3, a novel member of the voltage-gated K(+) channel. Reverse transcriptase-polymerase chain reaction analysis indicated that Kv6.3 was highly expressed in the brain. Electrophysiological studies indicated that homomultimeric Kv6.3 did not yield a functional voltage-gated ion channel. When Kv6.3 and Kv2.1 were co-expressed, the heteromultimeric channels displayed the decreased rate of deactivation compared to the homomultimeric Kv2.1 channels. Immunoprecipitation studies indicated that Kv6.3 bound with Kv2.1 in co-transfected cells. These results indicate that Kv6.3 is a novel member of the voltage-gated K(+) channel which functions as a modulatory subunit.

MeSH terms

  • Amino Acid Sequence
  • Cloning, Molecular
  • Delayed Rectifier Potassium Channels
  • Electric Conductivity
  • Humans
  • Ion Channel Gating
  • Molecular Sequence Data
  • Potassium Channels / classification
  • Potassium Channels / genetics
  • Potassium Channels / metabolism*
  • Potassium Channels, Voltage-Gated*
  • Protein Subunits
  • Sequence Homology, Amino Acid
  • Shab Potassium Channels
  • Tissue Distribution


  • Delayed Rectifier Potassium Channels
  • KCNB1 protein, human
  • KCNG3 protein, human
  • Kcng3 protein, rat
  • Potassium Channels
  • Potassium Channels, Voltage-Gated
  • Protein Subunits
  • Shab Potassium Channels

Associated data

  • GENBANK/AB070604
  • GENBANK/AB070605