Induction of mammalian cell death by a plant Bax inhibitor

FEBS Lett. 2002 Feb 13;512(1-3):308-12. doi: 10.1016/s0014-5793(02)02230-5.


Arabidopsis thaliana AtBI-1 is an orthologue of mammalian Bax inhibitor-1 capable of suppressing Bax-induced cell death in yeast as well as mammalian cells. Here we investigated whether or not AtBI-1 suppresses Bax-induced cell death using human fibrosarcoma HT1080 cells. Surprisingly, AtBI-1 did not block Bax-induced cell death, but it triggered apoptotic cell death in mammalian cells. The proapoptotic effect of AtBI-1 was blocked by the X-linked caspase inhibitor XIAP, suggesting that the cell death caused by AtBI-1 is similar to that caused by Bax.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Apoptosis Regulatory Proteins
  • Apoptosis*
  • Arabidopsis Proteins / genetics
  • Arabidopsis Proteins / pharmacology*
  • Caspase Inhibitors
  • Humans
  • Membrane Proteins / genetics
  • Membrane Proteins / pharmacology*
  • Models, Biological
  • Proteins / pharmacology
  • Proto-Oncogene Proteins / antagonists & inhibitors*
  • Proto-Oncogene Proteins c-bcl-2 / antagonists & inhibitors*
  • Recombinant Proteins / pharmacology
  • Species Specificity
  • Tumor Cells, Cultured
  • X-Linked Inhibitor of Apoptosis Protein
  • bcl-2-Associated X Protein


  • ATBI-1 protein, Arabidopsis
  • Apoptosis Regulatory Proteins
  • Arabidopsis Proteins
  • BAX protein, human
  • Caspase Inhibitors
  • Membrane Proteins
  • Proteins
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-bcl-2
  • Recombinant Proteins
  • TMBIM6 protein, human
  • X-Linked Inhibitor of Apoptosis Protein
  • XIAP protein, human
  • bcl-2-Associated X Protein