Review
. 2002 Mar;25(3):121-3; discussion 123-4.
doi: 10.1016/s0166-2236(00)02086-5.
'...and C is for Clioquinol' - the AbetaCs of Alzheimer's disease
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- PMID: 11852134
- DOI: 10.1016/s0166-2236(00)02086-5
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Review
'...and C is for Clioquinol' - the AbetaCs of Alzheimer's disease
Trends Neurosci.
2002 Mar.
Abstract
Alzheimer's disease (AD) is a devastating age-related neurodegenerative disorder that has been intensively studied over the last several years. In vitro and in vivo studies have led to an understanding of some of the physico-chemical properties of amyloid, a well-characterized hallmark of AD. Clioquinol is a drug that acts on amyloid by perturbing amyloid's metallo-chemistry, and Clioquinol treatment has been shown to be beneficial in a mouse model of AD. This short review examines the recent studies relating to Clioquinol and AD, and anticipates the imminent results of a Phase II trial of Clioquinol in AD, due in March 2002.
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