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Review
. 2002 Mar;25(3):121-3; discussion 123-4.
doi: 10.1016/s0166-2236(00)02086-5.

'...and C is for Clioquinol' - the AbetaCs of Alzheimer's disease

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Review

'...and C is for Clioquinol' - the AbetaCs of Alzheimer's disease

Simon Melov. Trends Neurosci. 2002 Mar.

Abstract

Alzheimer's disease (AD) is a devastating age-related neurodegenerative disorder that has been intensively studied over the last several years. In vitro and in vivo studies have led to an understanding of some of the physico-chemical properties of amyloid, a well-characterized hallmark of AD. Clioquinol is a drug that acts on amyloid by perturbing amyloid's metallo-chemistry, and Clioquinol treatment has been shown to be beneficial in a mouse model of AD. This short review examines the recent studies relating to Clioquinol and AD, and anticipates the imminent results of a Phase II trial of Clioquinol in AD, due in March 2002.

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