Pho85 and signaling environmental conditions

Trends Biochem Sci. 2002 Feb;27(2):87-93. doi: 10.1016/s0968-0004(01)02040-0.


Through its association with a family of ten cyclins, the Pho85 cyclin-dependent kinase is involved in several signal transduction pathways in the yeast Saccharomyces cerevisiae. The responses mediated by Pho85 include cell-cycle progression and metabolism of nutrients such as phosphate and carbon sources. Although these responses require the phosphorylation of different substrates, and have different mechanistic consequences as a result of this phosphorylation, all appear to be involved in responses to changes in environmental conditions. Few of the activating signals or regulated targets have been unambiguously identified, but the kinase activity of Pho85 appears to inform the cell that the current environment is satisfactory.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Cell Cycle / physiology*
  • Cyclin-Dependent Kinases / physiology*
  • Environmental Exposure / adverse effects
  • Fungal Proteins / metabolism
  • Gene Expression Regulation, Fungal / genetics*
  • Phosphorylation
  • Repressor Proteins / physiology*
  • Saccharomyces cerevisiae / growth & development
  • Saccharomyces cerevisiae / metabolism*
  • Saccharomyces cerevisiae Proteins / physiology*
  • Signal Transduction / physiology


  • Fungal Proteins
  • Repressor Proteins
  • Saccharomyces cerevisiae Proteins
  • Cyclin-Dependent Kinases
  • PHO85 protein, S cerevisiae