Antiallergic effect of flavonoid glycosides obtained from Mentha piperita L

Biol Pharm Bull. 2002 Feb;25(2):256-9. doi: 10.1248/bpb.25.256.


Six flavonoid glycosides, eriocitrin (1), narirutin (2), hesperidin (3), luteolin-7-O-rutinoside (4), isorhoifolin (5), diosmin (6), rosmarinic acid (7) and 5,7-dihydroxycromone-7-O-rutinoside (8), were isolated from the aerial part of Mentha piperita L. Among these compounds, compound 4 showed a potent inhibitory effect on histamine release induced by compound 48/80 and antigen-antibody reaction. This compound was more effective than luteolin and luteolin-7-O-glucoside in inhibiting histamine release from rat peritoneal mast cells. Compound 4 also caused a dose-related inhibition of the antigen-induced nasal response and significant effects were observed at doses of 100 and 300 mg/kg. These results indicate that compound 4 may be clinically useful in alleviating the nasal symptoms of allergic rhinitis.

MeSH terms

  • Animals
  • Anti-Allergic Agents / pharmacology*
  • Flavonoids / pharmacology*
  • Glycosides / pharmacology*
  • Histamine Release / drug effects
  • Male
  • Mentha / chemistry*
  • Rats
  • Rats, Wistar
  • Sneezing / drug effects


  • Anti-Allergic Agents
  • Flavonoids
  • Glycosides