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, 13 (2), 55-60

Nuclear Receptor Coregulators: Multiple Modes of Modification


Nuclear Receptor Coregulators: Multiple Modes of Modification

Ola Hermanson et al. Trends Endocrinol Metab.


Many proteins have been characterized as coregulators that can be recruited by DNA-binding nuclear receptors to influence transcriptional regulation. Recent genetic and biochemical studies have shown that cellular levels of coregulators are crucial for nuclear receptor-mediated transcription, and many coregulators have been shown to be targets for diverse intracellular signaling pathways and post-translational modifications. This review focuses on the different modes of regulation of nuclear receptor coregulators and the implications for tissue- and context-specific transcriptional responses to hormone and membrane receptor signaling.

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