Nuclear receptor coregulators: multiple modes of modification

Trends Endocrinol Metab. 2002 Mar;13(2):55-60. doi: 10.1016/s1043-2760(01)00527-6.


Many proteins have been characterized as coregulators that can be recruited by DNA-binding nuclear receptors to influence transcriptional regulation. Recent genetic and biochemical studies have shown that cellular levels of coregulators are crucial for nuclear receptor-mediated transcription, and many coregulators have been shown to be targets for diverse intracellular signaling pathways and post-translational modifications. This review focuses on the different modes of regulation of nuclear receptor coregulators and the implications for tissue- and context-specific transcriptional responses to hormone and membrane receptor signaling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Nucleus / genetics
  • Cell Nucleus / physiology*
  • Cytoplasm / physiology
  • DNA-Binding Proteins / metabolism
  • Gene Expression Regulation / genetics
  • Gene Expression Regulation / physiology
  • Humans
  • Phosphorylation
  • Receptors, Cytoplasmic and Nuclear / biosynthesis
  • Receptors, Cytoplasmic and Nuclear / genetics
  • Receptors, Cytoplasmic and Nuclear / physiology*
  • Transcription, Genetic / genetics


  • DNA-Binding Proteins
  • Receptors, Cytoplasmic and Nuclear