DNA polymerase beta

Int J Biochem Cell Biol. 2002 Apr;34(4):321-4. doi: 10.1016/s1357-2725(01)00131-5.


Mammalian DNA polymerase beta(beta-pol) is a single polypeptide chain enzyme of 39kDa. beta-pol has enzymatic activities appropriate for roles in base excision repair and other DNA metabolism events involving gap-filling DNA synthesis. Many crystal structures of beta-pol complexed with dNTP and DNA substrates have been solved, and mouse fibroblast cell lines deleted in the beta-pol gene have been examined. These approaches have enhanced our understanding of structural and functional aspects of beta-pol's role in protecting genomic DNA.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • DNA Polymerase beta / chemistry
  • DNA Polymerase beta / genetics
  • DNA Polymerase beta / metabolism*
  • DNA Repair
  • DNA, Catalytic / metabolism
  • Exons
  • Humans
  • Lyases / chemistry
  • Lyases / metabolism
  • Models, Molecular
  • Molecular Weight
  • Protein Structure, Secondary
  • Protein Structure, Tertiary


  • DNA, Catalytic
  • DNA Polymerase beta
  • Lyases