Diagnosis and management of primary aldosteronism in pregnancy: case report and review of the literature

Am J Perinatol. 2002 Jan;19(1):31-6. doi: 10.1055/s-2002-20170.


Primary aldosteronism rarely complicates pregnancy. We present a woman with primary aldosteronism in pregnancy associated with severe preeclampsia. A 33-year-old Japanese woman with hypertension was referred to our hospital at 25 weeks of gestation. Her blood pressure was 180/100 mmHg, and laboratory tests identified a low serum potassium level and moderate proteinuria on urinalysis. The fetus was diagnosed with growth restriction. Plasma renin activity (PRA) value was 2.2 ng/mL/h and plasma aldosterone concentration (PAC) was elevated (260 pg/mL). The patient was treated medically. At 27 weeks of gestation, we noted persistent late fetal heart rate decelerations associated with uterine contractions. Therefore, elective caesarean section was performed and she was delivered of a 698-g female. After delivery, PRA declined and PAC remained elevated. Abdominal computerized tomography scan and I131-iodochoresterol scan revealed a tumor in the left adrenal gland. Laparoscopic adrenalectomy was performed and confirmed the clinical diagnosis.

Publication types

  • Case Reports

MeSH terms

  • Adenoma / complications
  • Adenoma / diagnosis
  • Adenoma / surgery
  • Adrenal Gland Neoplasms / complications
  • Adrenal Gland Neoplasms / diagnosis*
  • Adrenal Gland Neoplasms / surgery*
  • Adrenalectomy
  • Adult
  • Aldosterone / blood
  • Cesarean Section
  • Female
  • Humans
  • Hyperaldosteronism / diagnosis*
  • Hyperaldosteronism / etiology*
  • Infant, Newborn
  • Pre-Eclampsia / diagnosis
  • Pregnancy
  • Pregnancy Complications / diagnosis*
  • Pregnancy Complications / etiology*
  • Renin / blood


  • Aldosterone
  • Renin