Inhibition of acetylcholinesterase activity by essential oil from Citrus paradisi

Nat Prod Lett. 2001;15(3):205-10. doi: 10.1080/10575630108041281.

Abstract

Inhibition of acetylcholinesterase (AChE) activity by essential oils of Citrus paradisi (grapefruit pink in USA) was studied. Inhibition of AChE was measured by the colorimetric method. Nootkatone and auraptene were isolated from C. paradisi oil and showed 17-24% inhibition of AChE activity at the concentration of 1.62 microg/mL.

MeSH terms

  • Acetylcholinesterase / blood*
  • Animals
  • Cattle
  • Cholinesterase Inhibitors / chemistry
  • Cholinesterase Inhibitors / isolation & purification*
  • Cholinesterase Inhibitors / pharmacology
  • Citrus / chemistry*
  • Coumarins / chemistry
  • Coumarins / isolation & purification*
  • Coumarins / pharmacology
  • Dose-Response Relationship, Drug
  • Erythrocytes / enzymology
  • Gas Chromatography-Mass Spectrometry
  • Inhibitory Concentration 50
  • Kinetics
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Oils / chemistry
  • Plant Oils / isolation & purification*
  • Plant Oils / pharmacology
  • Plants, Medicinal / chemistry*
  • Polycyclic Sesquiterpenes
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology
  • Spectrophotometry, Infrared
  • United States

Substances

  • Cholinesterase Inhibitors
  • Coumarins
  • Plant Oils
  • Polycyclic Sesquiterpenes
  • Sesquiterpenes
  • Acetylcholinesterase
  • aurapten
  • nootkatone