Pharmacokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Seveso adults and veterans of operation Ranch Hand

J Expo Anal Environ Epidemiol. Jan-Feb 2002;12(1):44-53. doi: 10.1038/sj.jea.7500201.

Abstract

A combined analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) elimination in Seveso adults and Ranch Hand veterans found a period of fast elimination within the first 0.27 years after exposure in Seveso, followed by a period of slower elimination between 3 and 16.35 years from exposure. The mean TCDD elimination rate within the first 0.27 years after exposure among six adult males in the Seveso cohort was 2.0646 year(-1) (half-life=0.34 years). The mean rate from 3 to 16.35 years was 0.1011 year(-1) (half-life=6.9 years). The mean Ranch Hand elimination rate, 00924 year(-1) (half-life=6.9 years), measured between 9 and 33 years after exposure, was significantly less than the Seveso mean in the first 0.27 years after exposure, but not significantly different from the Seveso mean between 3 and 16.35 years after exposure. The fast elimination within the first 0.27 years followed by a slower rate after 3 years is consistent with the expected pattern in a two-compartment open model, with a distribution phase of rapid elimination followed by a slower elimination phase.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Accidents, Occupational / statistics & numerical data
  • Adult
  • Environmental Exposure / analysis*
  • Environmental Monitoring / statistics & numerical data*
  • Female
  • Humans
  • Italy
  • Male
  • Metabolic Clearance Rate
  • Occupational Exposure / analysis*
  • Polychlorinated Dibenzodioxins / pharmacokinetics*
  • Sex Distribution
  • Time Factors
  • United States
  • Veterans*

Substances

  • Polychlorinated Dibenzodioxins