Tandem application of sodium lauryl sulfate and n-propanol does not lead to enhancement of cumulative skin irritation

Acta Derm Venereol. 2001 Nov-Dec;81(6):403-5. doi: 10.1080/000155501317208327.


Irritant contact dermatitis has a broad spectrum of clinical features and is a leading cause of occupational disease worldwide. It has been shown previously that a combination of chemically different irritants may cause an additive effect compared to single application of these substances. In this study, tandem application of sodium lauryl sulfate and n-propanol was investigated in 20 human volunteers using non-invasive bioengineering methods, such as measurement of transepidermal water loss and chromametry. N-propanol did not enhance cumulative skin irritation when used with sodium lauryl sulfate, as has been reported for toluene. As n-propanol is the active ingredient in many disinfectants, this is of particular interest regarding occupational skin irritation in health care workers.

MeSH terms

  • 1-Propanol / administration & dosage
  • 1-Propanol / adverse effects*
  • Adult
  • Colorimetry
  • Dermatitis, Irritant / etiology
  • Dermatitis, Irritant / pathology*
  • Dermatitis, Irritant / physiopathology
  • Dermatitis, Occupational / etiology
  • Dermatitis, Occupational / pathology
  • Erythema / chemically induced
  • Erythema / pathology
  • Female
  • Humans
  • Irritants / administration & dosage*
  • Male
  • Skin / drug effects
  • Skin / pathology*
  • Sodium Dodecyl Sulfate / administration & dosage
  • Sodium Dodecyl Sulfate / adverse effects*
  • Water Loss, Insensible


  • Irritants
  • Sodium Dodecyl Sulfate
  • 1-Propanol