Immunohistochemical study of p185 HER2 and DF3 in primary breast cancer and correlation with CA-15-3 serum tumor marker

Cleanthi Dimas; M Frangos-Plemenos; E Kouskouni; A Kondis-Pafitis

doi:10.1046/j.1525-1438.2002.01073.x

Immunohistochemical study of p185 HER2 and DF3 in primary breast cancer and correlation with CA-15-3 serum tumor marker

Int J Gynecol Cancer. 2002 Jan-Feb;12(1):74-9. doi: 10.1046/j.1525-1438.2002.01073.x.

Authors

Cleanthi Dimas¹, M Frangos-Plemenos, E Kouskouni, A Kondis-Pafitis

Affiliation

¹ Department of Microbiology, Athens Medical School, Areteion Hospital, 76 Vas. Sofias Av., 11528 Athens, Greece. clair@matrix.kapatel.gr

PMID: 11860539
DOI: 10.1046/j.1525-1438.2002.01073.x

Abstract

Human epidermal growth factor receptor 2 (p185 HER2) oncoprotein immunohistochemical expression and DF3 antigen distribution were evaluated in 129 patients with primary breast cancer. p185 HER2 overexpession was positively correlated with the degree of differentiation, metastatic disease, progesterone receptors, and cytoplasmic distribution of DF3 antigen. p185 HER2 overexpression had prognostic significance for the disease-free interval.

MeSH terms

Antibodies, Monoclonal / immunology
Antigens, Neoplasm / metabolism*
Biomarkers, Tumor / analysis*
Breast Neoplasms / metabolism*
Breast Neoplasms / pathology
Breast Neoplasms / therapy
Carcinoma, Ductal, Breast / metabolism*
Carcinoma, Ductal, Breast / pathology
Carcinoma, Ductal, Breast / therapy
Cell Differentiation
Disease-Free Survival
Female
Humans
Immunoenzyme Techniques
Mucin-1 / blood
Mucin-1 / metabolism*
Peptide Fragments / metabolism*
Prognosis
Receptor, ErbB-2 / metabolism*
Receptors, Progesterone / metabolism

Substances

Antibodies, Monoclonal
Antigens, Neoplasm
Biomarkers, Tumor
MUC1 tandem repeat peptide
Mucin-1
Peptide Fragments
Receptors, Progesterone
Receptor, ErbB-2