Adenovirus and ileocecal intussusception

Lab Invest. 1975 Oct;33(4):347-51.


Intranuclear inclusion bodies were found by light microscopy in epithelial cells in more than one-third of the specimens from children operated on for ileocecal intussusception. Electron microscopic examination done on hematoxylin and eosin-stained slides showed the intranuclear inclusion bodies to be composed of viral particles in large and small crystalline arrays. Adenovirus of serotypes 2, 3, and 5 were isolated from the five cases with inclusions in which isolation was attempted. These findings strongly suggest a pathogenetic role for adenovirus in those cases of intussusception in which intranuclear inclusion bodies are found in the epithelial cells of the appendix or the terminal ileum.

MeSH terms

  • Adenoviridae / isolation & purification*
  • Appendix / pathology
  • Cecum / microbiology*
  • Cell Nucleus / ultrastructure
  • Child, Preschool
  • Epithelial Cells
  • Epithelium / ultrastructure
  • Female
  • Humans
  • Ileum / microbiology*
  • Ileum / pathology
  • Inclusion Bodies, Viral*
  • Infant
  • Intestinal Mucosa / ultrastructure
  • Intussusception / microbiology*
  • Intussusception / pathology
  • Male