T cell memory

Annu Rev Immunol. 2002;20:551-79. doi: 10.1146/annurev.immunol.20.100101.151926. Epub 2001 Oct 4.

Abstract

Typical immune responses lead to prominent clonal expansion of antigen-specific T and B cells followed by differentiation into effector cells. Most effector cells die at the end of the immune response but some of these cells survive and form long-lived memory cells. The factors controlling the formation and survival of memory T cells are reviewed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adjuvants, Immunologic / metabolism
  • Animals
  • Antigen-Presenting Cells / immunology
  • Antigens / metabolism
  • Apoptosis
  • Cell Differentiation
  • Cell Division
  • Cell Movement
  • Cytokines / metabolism
  • Homeostasis
  • Humans
  • Immunologic Memory*
  • Lymphocyte Activation
  • T-Lymphocytes / cytology
  • T-Lymphocytes / immunology*

Substances

  • Adjuvants, Immunologic
  • Antigens
  • Cytokines