Phagocytosis of microbes: complexity in action

Annu Rev Immunol. 2002;20:825-52. doi: 10.1146/annurev.immunol.20.103001.114744. Epub 2001 Dec 7.

Abstract

The phagocytic response of innate immune cells such as macrophages is defined by the activation of complex signaling networks that are stimulated by microbial contact. Many individual proteins have been demonstrated to participate in phagocytosis, and the application of high-throughput tools has indicated that many more remain to be described. In this review, we examine this complexity and describe how during recognition, multiple receptors are simultaneously engaged to mediate internalization, activate microbial killing, and induce the production of inflammatory cytokines and chemokines. Many signaling molecules perform multiple functions during phagocytosis, and these molecules are likely to be key regulators of the process. Indeed, pathogenic microorganisms target many of these molecules in their attempts to evade destruction.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Chemokines / biosynthesis
  • Cytokines / biosynthesis
  • Humans
  • Immunity, Innate
  • Inflammation / immunology
  • Membrane Proteins*
  • Microbiology
  • Models, Immunological
  • Phagocytes / immunology
  • Phagocytes / microbiology
  • Phagocytosis*
  • Receptors, Complement / metabolism
  • Receptors, IgG / metabolism
  • Receptors, Immunologic / metabolism
  • Receptors, Lipoprotein*
  • Receptors, Scavenger
  • Scavenger Receptors, Class B
  • Signal Transduction
  • Superoxides / metabolism

Substances

  • Chemokines
  • Cytokines
  • Membrane Proteins
  • Receptors, Complement
  • Receptors, IgG
  • Receptors, Immunologic
  • Receptors, Lipoprotein
  • Receptors, Scavenger
  • Scarb1 protein, mouse
  • Scavenger Receptors, Class B
  • Superoxides